efflux inhibitor-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T72521	Efflux inhibitor-1
	Efflux inhibitor-1 is a pyrazolopyrimidine efflux inhibitor. Efflux inhibitor-1 selectively targets toward ABCG2/BCRP over ABCB1 with IC 50 s of 0.45 μM and 2.17 μM, respectively .
T8596	Ceefourin 1		MRP
	Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.		MRP
T1050	Prazosin hydrochloride	Prazosin hydrochloride,Prazosin HCl,cp-12299-1,Peripress,Vasoflex,Minipress	Potassium Channel , MRP , Adrenergic Receptor , ABC , Autophagy
	Prazosin hydrochloride (Vasoflex) reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not completely known. Prazosin hydrochloride is a synthetic ...
T16339	Norverapamil hydrochloride	(±)-Norverapamil hydrochloride,D591 hydrochloride	Calcium Channel , P-gp , Drug Metabolite
	Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.		Calcium Channel , P-gp , Drug Metabolite
T19649	PF-06273340	PF 6273340,PF 06273340,PF6273340,PF-6273340	Trk receptor
	PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflu...		Trk receptor
T60165	VB124		Monocarboxylate transporter
	VB124 is an orally active, potent, and selective MCT4 inhibitor, demonstrating specificity in hindering lactate efflux, with IC50 values of 8.6 nM and 19 nM for lactate import and export, respectively, in MDA-MB-231 cell...		Monocarboxylate transporter
T74827	AcrB-IN-2
	Efflux pump-IN-2 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics . Efflux pump-IN-2 inhibits Nile Red (a known substrate of AcrB) efflux. Efflux pump-IN-2 does not disrupts the bact...
T81654	NorA-IN-1
	NorA-IN-1 (Compound 16), a NorA efflux pump inhibitor, has applications in the research of multidrug resistance [1]. It functions by impeding the NorA efflux pump in everted membrane vesicles.
T14915	CDK12-IN-E9		CDK
	CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux. It has a weak binding ability to CDK7/CyclinH complex (IC50> 1 μM).		CDK
T74828	AcrB-IN-3
	Efflux pump-IN-3, an AcrB efflux pump inhibitor, potentiates the effect of antibiotics by inhibiting the efflux of Nile Red (a known substrate of AcrB). It does not disrupt the bacterial outer membrane or exhibit toxicit...
T74829	AcrB-IN-4
	Efflux pump-IN-4, an AcrB efflux pump inhibitor, potentiate[s] the effects of antibiotics by inhibiting the efflux of Nile Red (a known substrate of AcrB). It does not disrupt the bacterial outer membrane or display toxi...
T82723	ChTX-Lq2
	Charybdotoxin-Lq2 (ChTX-Lq2) is a potent inhibitor of calcium-activated potassium efflux, exhibiting a dissociation constant (Kd) of 43 nanomolar (nM) [1].
T63267	P-gp/BCRP-IN-1
	P-gp/BCRP-IN-1 (compound 19) is a relatively safe, orally active, and efficient inhibitor of the efflux transporters P-gp and BCRP. By inhibiting their efflux function, it reverses resistance and enhances the oral bioava...
T13222	TTT-28		Others
	TTT-28 is a thiazole-valine peptidomimetic, and is a selective ABCB1 (P-gp/MDR1) inhibitor with high efficacy and low toxicity, which reverses the ATP-binding cassette sub-family B member 1 (ABCB1)-mediated Multidrug res...		Others
T37824	MCT4-IN-1	MCT4-IN-1
	MCT4-IN-1 is an orally active and selective monocarboxylate transporter 4 (MCT4/SLC16A3) inhibitor with an IC50 of 77 nM and a Ki of 11 nM. MCT4-IN-1 targets to the cytosolic domain of MCT4. MCT4-IN-1 results in lactate ...
T27211	DS-8587	DS 8587,DS8587,DS-8587 free
	DS-8587 is a DNA topoisomerase inhibitor. DS-8587 exhibits potent antibacterial activity against quinolone-resistant A. baumannii isolates that harbor mutations in quinolone resistance-determining regions. DS-8587 signif...
T78200	BDM91270
	BDM91270 (compound 29) serves as an inhibitor of the E. coli AcrAB-TolC efflux pump, displaying an EC90 value of 0.6 μM against wild-type E. coli AcrB. It has applications in research on Escherichia coli drug resistance ...
T79261	P-gp inhibitor 15
	P-gp Inhibitor 15 (compound 7a), a nonsubstrate inhibitor of P-glycoprotein (Pgp), inhibits Pgp-ATPase activity and interferes with Pgp-mediated Rhodamine123 efflux. Additionally, this compound enhances the inhibitory ef...
T61956	BACE1/2-IN-1
	BACE1/2-IN-1 (compound 34) is an effective BACE1 and BACE2 inhibitor with IC50 of 0.01 and 0.0053 μM, respectively. BACE1/2-IN-1 has lower Pgp efflux ratio and improved passive permeability. The metabolic stability of BA...
T80001	Majoranaquinone		Antibiotic
	Majoranaquinone demonstrates potent antibacterial activity against four Staphylococcus strains, one Moraxella strain, and one Enterococcus strain. It also acts as an effective efflux pump inhibitor in Escherichia coli AT...		Antibiotic